- PlayStation 1 (emulator: PCSX ReARMed)
- Super Nintendo (emulator: SNES9x Next)
- Nintendo Entertainment System (emulator: FCEUmm / NEStopia)
- GameBoy / GameBoy Color (emulator: Gambatte)
- GameBoy Advance (emulator: VBA Next)
- Arcade (emulator: Final Burn Alpha)
- Neo Geo Pocket Color (emulator: Mednafen NGP)
- Virtual Boy (emulator: Mednafen VB)
- Sega Genesis/Mega Drive (emulator: Genesis Plus GX)
- Sega Master System/Sega Game Gear (emulator: Genesis Plus GX)
- Sega CD / Mega CD (emulator: Genesis Plus GX)
- PC Engine / PC Engine CD (emulator: Mednafen PCE Fast)
- WonderSwan Color / Crystal (emulator: Mednafen Wonderswan)
- Cave Story (game engine: NX Engine)
- Doom 1 / Doom 2 / Ultimate Doom / Final Doom (game engine: prBoom)
1.2.2更新内容：
1.2版本发布内容：http://www.libretro.com/index.php/retroarch-1-2-july-4-release-kickoff/